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Nanoparticle-arsenic combination makes for more potent anticancer agent
By admin at 2006-11-14 07:16
Nanoparticle-arsenic combination makes for more potent anticancer agent
Thomas O’Halloran, Ph.D., and colleagues at Northwestern University’s Nanomaterials for Cancer Diagnostics and Therapeutics Center for Cancer Nanotechnology Excellence (CCNE) report on a new method of incorporating arsenic trioxide into lipid particles in order to aid in entrance to tumor cells. What makes their method unique is that by prefilling the lipid spheres with metals, the arsenic trioxide binds tighter and releases acetic acid, which pushes the equilibrium or arsenic towards entering the cell, sort of a positive feedback mechanism.

[url]http://www.nanowerk.com/news/newsid=1017.php[/url]

The spheres release the ASO3 when they reach the acidic ph of the tumor cell interior.



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