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Experts issue call to reconsider screening for breast cancer and prostate cancer
By Dross at 2009-10-21 18:13
Experts issue call to reconsider screening for breast cancer and prostate cancer

Twenty years of screening for breast and prostate cancer – the most diagnosed cancer for women and men – have not brought the anticipated decline in deaths from these diseases, argue experts from the University of California, San Francisco and the University of Texas Health Science Center at San Antonio in an opinion piece published in the "Journal of the American Medical Association."

Instead, overall cancer rates are higher, many more patients are being treated, and the incidence of aggressive or later-stage disease has not been significantly decreased, the authors conclude. Current screening programs are leading to "potential tumor over-detection and over-treatment," they write in the Oct. 21, 2009 issue of JAMA.

"Screening does provide some benefit, but the problem is that the benefit is not nearly as much as we hoped and comes at the cost of over-diagnosis and over-treatment," said Laura Esserman, MD, MBA, professor of surgery and radiology, director of the UCSF Carol Franc Buck Breast Care Center, and co-leader of the breast oncology program at the UCSF Helen Diller Family Comprehensive Cancer Center.

"We need to focus on developing new tools to identify men and women at risk for the most aggressive cancers, to identify at the time of diagnosis those who have indolent or 'idle' tumors that are not life-threatening," she added. "If we can identify groups of patients that don't need much treatment, or don't need to be screened, wouldn't that be great? Screening is by no means perfect. We should want to make it better. For both breast and prostate cancer we need to invest in changing our focus from the cancers that won't kill people to the ones that do."

Breast cancer, the most common cancer in women, is a devastating and costly disease, striking more than 200,000 women annually and killing more than 40,000 women each year, reports the American Cancer Society. Prostate cancer is the most common form of cancer in men and the second most common cause of cancer death after lung cancer. This year, an estimated 192,280 men will be diagnosed with the disease, and 27,360 men will die from it, according to estimates from the American Cancer Society.

The two diseases account for 26 percent of all cancers in the U.S., with an estimated 386,560 patients diagnosed annually.

Because of remarkable survival rates when the diseases are treated before they spread, screening for both cancers has been promoted on the assumption that early detection and treatment is the best way to reduce deaths. In turn, much of the U.S. population undergoes routine screening for the cancers: About half of at-risk men have a routine prostate-specific antigen test and 75 percent have previously had a PSA test, and about 70 percent of women older than 40 report having had a recent mammogram. More than $20 billion is spent annually screening for the two diseases in the U.S.

The screenings have resulted in a "significant increase" in early cancers being detected, according to the article authors. Because of PSA testing, the chances of a man being diagnosed with prostate cancer have nearly doubled: In 1980, a white man's lifetime risk of the cancer was 1 in 11; today it is 1 in 6. Similarly, a woman's lifetime risk of breast cancer was 1 in 12 in 1980; today it is 1 in 8. And, if ductal carcinomaterm in situ is included, the risk of being diagnosed with breast cancer, like prostate cancer, has nearly doubled as well.

But the authors found that while deaths have dropped for both cancers over the last 20 years, "the contribution from screening is uncertain." They also found that many patients are undergoing treatment from cancers that actually pose minimal risk.

A comparison of prostate cancer incidence rates in the U.S. to the United Kingdom, where PSA screening has not been widely adopted, "did not result in significant differences in mortality," the authors write. For breast cancer the relative reduction in deaths from screening has also been limited.

The authors said that breast cancer and prostate cancer screening has not led to a more significant drop in deaths in the U.S. for two primary reasons: Screening increases the detection of slow growing and indolent tumors, and it often misses the most aggressive cancers because many may not be detected early enough for cure.

"In other words, tumor biology dictates and trumps stage, so the basic assumption of these screening programs that finding and treating early stage disease will prevent late stage or metastaticterm disease may not always be correct," they state.

Periodic screening may find some tumors early, but patients may not be screened often enough for lethal tumors to be detected in time to prevent death, the authors conclude: "Without the ability to distinguish cancers that pose minimal risk from those posing substantial risk and with highly sensitive screening tests, there is an increased risk that the population will be over-treated."

"People will think that we're saying screening is bad, and nothing could be further from the truth," said Ian Thompson, MD, who has authored about 400 scientific articles addressing prevention, early detection, and treatment for prostate, kidney, and bladder cancers. "What we are saying is that if you want to stop suffering and death from these diseases, you can't rely on screening alone."

"The basic assumption that screening programs that find and treat early stage disease will then prevent late-stage disease, or prevent cancer from spreading, may not always be correct," added Thompson. "If a tumor is aggressive, finding it early may not prevent death."

Thompson is professor and chairman of the Department of Urology and holds the Glenda and Gary Woods Distinguished Chair in Genitourinary Oncology at the Cancer Therapy & Research Center at the UT Health Science Center at San Antonio and the Henry B. and the Edna Smith Dielmann Memorial Chair in Urologic Science at the UT Health Science Center. He led the Prostate Cancer Prevention Trial, a study of 18,882 men from around the U.S. that demonstrated that the drug finasteride reduces a man's risk of prostate cancer by 24.8 percent.

In contrast to breast and prostate cancer, screening for cervical and colon cancer -- and the removal of abnormal tissue – has led to a significant drop in invasive cancer. Screening is "most successful when pre-malignant lesions can be detected and eliminated" such as during colonoscopies, said the authors.

The authors suggest that to improve screening, "a new focus is recommended for research and care to identify markers that discriminate minimal-risk from high-risk disease (and) identify less aggressive interventions for minimal-risk disease to reduce treatment burden for patients and society."

The authors list four recommendations in their call to action for early detection and prevention:

  1. Develop tests to distinguish between cancers that are lethal and those that are low-risk.
  2. Reduce treatment for low-risk disease. Diagnosing cancers that don't kill the patient has led to treatment that may do more harm than good.
  3. Develop tools for physicians and patients to help them make informed decisions about prevention, screening, biopsy and treatment. Offer treatments individually tailored to a patient's tumor.
  4. Work to identify the people at highest risk for cancer and use proven preventive interventions.

"Over the years we have worked hard to find new treatments and new ways of finding disease and many of these interventions when appropriately assessed have saved lives," said Otis W. Brawley, MD, chief medical officer of the American Cancer Society, and professor of hematology, oncology and epidemiology at Emory University.

"It is very appropriate that we occasionally step back, assess and reflect on what we in medicine are doing," he added. "In the case of some screening for some cancers, modern medicine has overpromised. Some of our successes are not as significant as first thought. Cancer is a complicated disease and too often we have tried to simplify it and simplify messages about it, to the point that we do harm to those we want to help."



1 comment | 2353 reads

by gdpawel on Mon, 2009-11-02 10:31
Herman Kattlove is a retired medical oncologist. He was a medical editor for the American Cancer Society where he helped develop much of the information about specific cancers that is posted on the website at [url]www.cancer.org[/url]. He retired from the ACS in November, 2006.

How useful is cancer screening?

Well, if you ask around, most people think it is pretty effective. In the Journal of the National Cancer Institute, researchers from Europe published some numbers on what people think. They asked residents of several European countries how effective they think are mammography screening for breast cancer and PSA testing for prostate cancer. Specifically, if 1000 people were screened on a regular schedule, how many lives would be saved?

On average, most thought that around 50 lives would be saved for every 1000 person screened for either cancer. Not even close. The real numbers are these: If 1000 women over age 50 are screened for breast cancer every year, one life would be saved. This number would be lower if the women were younger (breast cancer occurs much less often in young women). Still, one life is important and this isn’t a bad outcome, even if many of the screened women have to undergo biopsies for spots on the mammogram that turn out not to be cancer.

The results of screening for prostate cancer are even less spectacular. Maybe one out of 2000 men who are between age 59 and 70 and screened regularly will be saved at the end of 10 years. But remember, this is a disease of old men and that guy who is saved will probably not last that much longer anyway. And here, there is a much bigger problem. A lot of men will undergo biopsy (not fun) and many will have prostate cancer that will never spread and kill. Still, they will receive treatment that can leave them incontinent (unable to hold their urine – think diapers) and impotent (Viagra usually won’t help). But their lives won’t be saved because prostate cancer isn’t very dangerous and lots of other disease can take them away before the prostate cancer does.

And just this week, another potential screening test was thrown into doubt. Remember all the excitement about screening for lung cancer with CT scans. Well, it doesn’t work. A new study, from Italy, was just published in the American Journal of Respiratory and Critical Care. The Italian researchers studied men who had smoked at least one pack a day for 20 years. Half received CT scans and the other half didn’t. After 3 years, on average, the death rate from lung cancer was the same in both groups. More cancers were found in the screened men, but no fewer deaths. This is the same result that was found 30 years ago when smokers were screened with chest x-rays. More cancers were found, but no more lives saved. No one knows why – perhaps some of the small cancers found on x-ray might have gone away spontaneously.

Now I firmly believe that screening for cervical cancer (pap smear) is worthwhile. It finds early precancerous and cancerous changes that can be easily treated. Likewise I’m for colonoscopy or other ways to screen for colorectal cancer (although there aren’t good studies proving this actually does save lives).

So mammography is probably OK if you are older than 50, pap smears and colonoscopy for the proper age groups (younger women for paps and people older than 50 for colonoscopy). But screening for prostate cancer is probably not helpful for most. And getting a CT scan to screen for lung cancer is probably useless.

So stop smoking and lead a healthy life. This is more important than all the screening in the world.

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