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Old 04-22-2007, 11:28 AM
Dross Dross is offline
Join Date: Nov 2006
Posts: 883
Default Translocation Kidney Cancer after Chemotherapy in Childhood

A new story entry has been added:

Translocation Kidney Cancer after Chemotherapy in Childhood

This article out of Johns Hopkins reviewed the risk of renal cell carcinoma occurring as a [B]secondary [/B]malignancy after [B]chemotherapy [/B]in childhood. It is known that children who survive cancer are at the risk of developing another malignancy 20 times more likely than the general population. This study described the clinical, pathologic, cytogenetic, and molecular data on six translocation renal cell carcinomas that arose in five patients who had received chemotherapy.At the time of diagnosis, the children were between the ages of 6-22 years. Histologically, the tumor showed typical features that are described for translocation renal cell carcinomas. At the molecular level, three of the tumors contained the ASPL-TFE3 fusion; two contained Alpha-TFEB and one contained PRCC-TFE3. The time span between chemotherapy and the diagnosis of these renal cell carcinomas ranged from 4-13 years. The indications varied and including [B]acute promyelocytic leukemia, acute myeloid leukemia, bilateral Wilms' tumor, systemic lupus erythematosu[/B]s, and a conditioning regimen of bone marrow transplantation secondary to Hurler's syndrome. This latter patient also received radiation.
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