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Tumor-Cell Death, Autophagy, and Immunity
By gdpawel at 2012-03-24 12:44

A new finding in basic science should trigger a "change in thinking" about how cancer drugs might be developed and tested for maximum effectiveness, says Louis M. Weiner, M.D., director of the Georgetown Lombardi Comprehensive Cancer Center, in a "Clinical Implications of Basic Research" article titled Tumor-Cell Death, Autophagy, and Immunity published in the March 22, 2012 issue of the New England Journal of Medicine (NEJM).

read more | 7 comments | 10106 reads

For Personalizing Cancer Therapy, Metabolic Profiles Are Essential
By gdpawel at 2012-02-09 13:12

One way to tackle a tumor is to take aim at the metabolic reactions that fuel their growth. But a report in the February Cell Metabolism, a Cell Press Publication, shows that one metabolism-targeted cancer therapy will not fit all. That means that metabolic profiling will be essential for defining each cancer and choosing the best treatment accordingly, researchers say.

read more | 4 comments | 13145 reads

Biomarker for Avastin
By gdpawel at 2011-11-25 10:07
For some time, clinicians have been grumbling about not having a biomarker for Avastinterm or any other anti-angiogenesis compound to better help choose which patients would be most likely to respond, thereby avoiding the need to treat everyone to gain a benefit in a few.

One of the biggest challenges with Vascular Endothelial Growth Factor (VEGFterm) therapy has been the lack of a predictive biomarker.

read more | 3 comments | 19960 reads

Personalized Cancer Cytometrics More Accurate than Molecular Gene Testing
By gdpawel at 2011-09-05 11:20


Clinical Trial Finds Personalized Cancer Cytometrics More Accurate than Molecular Gene Testing


In the first head-to-head clinical trial comparing gene expression patterns with Personalized Cancer Cytometric testing (also known as “functional tumor cell profiling” or “chemosensitivity testing”), Personalized Cancer Cytometrics was found to be substantially more accurate.


read more | 7 comments | 19809 reads

PSA test for men could get a second life for breast cancer in women
By Dross at 2011-07-16 03:10


The widely known PSA blood test for prostate cancer in men may get a second life as a much-needed new test for breast cancer, the most common form of cancer in women worldwide, scientists are reporting in a new study in the ACS journal Analytical Chemistry.

read more | 19517 reads

Bone marrow transplant survival more than doubles for young high-risk leukemia patients
By Dross at 2011-07-15 20:56


Bone marrow transplant survival more than doubled in recent years for young, high-risk leukemiaterm patients treated at St. Jude Children's Research Hospital, with patients who lacked genetically matched donors recording the most significant gains. The results are believed to be the best ever reported for leukemia patients who underwent bone marrow transplantation.

read more | 19406 reads

Novel Experimental Agent Is Highly Active In CLL Patients, Interim Study Shows
By Dross at 2011-06-06 22:49

 COLUMBUS, Ohio – An interim analysis of a phase II clinical trial indicates that a novel experimental agent for chronic lymphocytic leukemiaterm (CLL) is highly active and well tolerated both in patients who are undergoing treatment for the first time and those who have relapsed and are resistant to other therapy. 

read more | 19071 reads

The Three Rs Of Cancer Survival
By gdpawel at 2011-05-31 07:06

Solid tumours such as brain tumours are highly resistant to chemotherapyterm and radiation. One reason for this is a ‘reduce, reuse, recycle’ strategy that these tumours use to survive treatment. By developing a cancer drug that targets this recycling pathway, Malaghan Institute of Medical Research scientists have struck upon a novel approach for combating otherwise resistant and aggressive cancers.

read more | 19829 reads

New drug shrinks cancer in animals, U-M study shows
By Dross at 2011-04-06 23:21

ANN ARBOR, Mich. — A study led by researchers at the University of Michigan Comprehensive Cancer Center showed in animal studies that new cancer drug compounds they developed shrank tumors, with few side effects.

read more | 18946 reads

Catching cancer with carbon nanotubes
By Dross at 2011-03-31 22:23

A Harvard bioengineer and an MIT aeronautical engineer have created a new device that can detect single cancer cells in a blood sample, potentially allowing doctors to quickly determine whether cancer has spread from its original site. 

read more | 4 comments | 19144 reads

A new high-resolution method for imaging below the skin using a liquid lens
By Dross at 2011-02-22 03:34

 University of Rochester optics professor Jannick Rolland has developed an optical technology that provides unprecedented images under the skin's surface. The aim of the technology is to detect and examine skin lesions to determine whether they are benign or cancerous without having to cut the suspected tumor out of the skin and analyze it in the lab.

read more | 19283 reads

Reprogrammed stem cells hit a roadblock
By Dross at 2011-02-22 03:01


It's a discordant note in the symphony of good news that usually accompanies stem cell research announcements. Stem cells hold enormous promise in regenerative medicine, thanks to their ability to regenerate diseased or damaged tissues. They have made it possible to markedly improve the effectiveness of many medical treatments – muscle regeneration in cases of dystrophy, skin grafts for treating burn victims, and the treatment of leukemiaterm via bone marrow transplants.

read more | 1 comment | 18767 reads

Losing hair at 20 is linked to increased risk of prostate cancer in later life
By Dross at 2011-02-17 01:56

Men who start to lose hair at the age of 20 are more likely to develop prostate cancer in later life and might benefit from screening for the disease, according to a new study published online in the cancer journal, Annals of Oncology [1] today.

read more | 18349 reads

Projections of the Cost of Cancer Care in the United States: 2010-2020
By gdpawel at 2011-01-13 22:24

Projections of the Cost of Cancer Care in the United States: 2010-2020

Angela B. Mariotto, K. Robin Yabroff, Yongwu Shao, Eric J. Feuer and Martin L. Brown

Angela B. Mariotto, PhD, Surveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Ste 504, MSC 8317, 6116 Executive Blvd, MSC 7344, Bethesda, MD 20892-7344

Current estimates of the costs of cancer care in the United States are based on data from 2003 and earlier. However, incidence, survival, and practice patterns have been changing for the majority of cancers.

read more | 16 comments | 17447 reads

New Blood Test That Counts Circulating Tumor Cells To Be Developed
By gdpawel at 2011-01-04 22:03

Using next-generation Circulating Tumor Cell (CTC) technology to capture, count and characterize circulating tumor cells in patients' blood, Johnson and Johnson and Massachusetts General Hospital hope to equip doctors with a more advanced non-invasive way to find out from a few cells how much a cancer has spread, personalize treatment for patients, and monitor their progress.

Circulating tumor cells (CTCs) are cells that have come away from a primary tumor, are circulating in the bloodstream, and have the potential to seed secondary tumors in another part of the body.

read more | 6 comments | 14490 reads


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