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Brighton researchers' discovery may prolong cancer patients’ lives
By gdpawel at 2013-03-20 08:57

Cancer patients around the world could have their lives extended thanks to a discovery made by Sussex scientists.

Researchers at the University of Sussex, who have been working with the Institute of Cancer Research, have found that a cutting-edge cancer drug may be able to keep patients alive for longer than they live now.

The discovery by the researchers, who looked at exactly how the drugs attack tumours, has been hailed as “unexpected and exciting”.

The drugs, known as kinase inhibitors, are a new type of treatment, with 25 currently in use on a variety of cancers.

read more | 5 comments | 2238 reads

For Smokers, Low Levels of Vitamin D May Lead to Cancer
By Dross at 2013-03-16 05:26

New research appearing online today in Clinical Chemistry, the journal of AACC, shows that decreased levels of vitamin D may predispose smokers to developing tobacco-related cancer. This study illustrates that simple vitamin D blood tests and supplements have the potential to improve smokers' health.  In the U.S. alone, cigarette smoking accounts for more deaths annually than HIV, illegal drugs, alcohol, motor vehicle injuries, suicides, and murders combined.

read more | 1 comment | 1910 reads

Small molecules in the blood might gauge radiation effects after exposure
By Dross at 2013-02-26 23:50

Currently, doctors have no way to accurately measure damage to the body soon after a person is exposed to ionizing radiation.
It is therefore difficult to know whether a person is likely to suffer serious effects after an occupational or accidental exposure.
This animal study shows that radiation exposure alters the levels of certain small molecules in the blood, perhaps offering a reliable measure of damage to the body.

read more | 2 comments | 2294 reads

Molecular master switch for pancreatic cancer identified, potential predictor of treatment outcome
By Dross at 2013-02-13 23:38

PHILADELPHIA – A recently described master regulator protein may explain the development of aberrant cell growth in the pancreas spurred by inflammation

A team from the Perelman School of Medicine at the University of Pennsylvania profiled gene expression of mouse pancreatic ductal and duct-like cells from different states - embryonic development, acute pancreatitis and K-ras mutation-driven carcinogenesis - to find the molecular regulation of these processes.

read more | 3 comments | 2288 reads

Emerging cancer drugs may drive bone tumors
By Dross at 2013-02-13 23:32

Cancer drugs should kill tumors, not encourage their spread. But new evidence suggests that an otherwise promising class of drugs may actually increase the risk of tumors spreading to bone, according to researchers at Washington University School of Medicine in St. Louis.

The drugs, IAP antagonists, block survival signals that many cancer cells rely on to stay alive. Working in mice, the investigators found that targeting the same protein that makes tumors vulnerable to death also overactivates cells called osteoclasts, which are responsible for tearing down bone.

read more | 2 comments | 2186 reads

Chemotherapy Recommendations Based on Published Reports of Clinical Trials
By gdpawel at 2013-01-28 10:47

The American Society of Clinical Oncologists (ASCO) says oncologists should make chemotherapy treatment recommendations on the basis of published reports of clinical trials and a patient’s health status and treatment preferences.

How about published reports of clinical trials?

More chemotherapy is given for breast cancer than for any other form of cancer and there have been more published reports of clinical trials for breast cancer than for any other form of cancer.

read more | 8 comments | 2618 reads

Change in PSA levels over time can help predict aggressive prostate cancer
By Dross at 2013-01-17 06:01

Measurements taken over time of prostate specific antigen, the most commonly used screening test for prostate cancer in men, improve the accuracy of aggressive prostate cancer detection when compared to a single measurement of PSA, according to a Kaiser Permanente study published today in the British Journal of Urology International.

read more | 4 comments | 2112 reads

Researchers reveal aggressive breast cancer's metastatic path
By Dross at 2013-01-17 05:22

Scientists at Weill Cornell Medical College have discovered the molecular switch that allows aggressive triple negative breast cancer cells to grow the amoeba-like protrusions they need to crawl away from a primary tumor and metastasize throughout the body. Their findings, published in Cancer Cell, suggest a novel approach for developing agents to treat cancer once it has spread.

read more | 1925 reads

U.S. FDA Grants Priority Review to Boehringer Ingelheim's Afatinib NDA for EGFR Mutation-Positive Advanced NSCLC
By Dross at 2013-01-15 23:30

Boehringer Ingelheim Pharmaceuticals Inc. (BIPI) today announced that the New Drug Application (NDA) for its investigational oncology compound afatinib has been accepted for filing and granted Priority Review by the U.S. Food and Drug Administration (FDA). The application for afatinib is currently under review for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with an epidermal growth factor receptor (EGFR) mutation as detected by an FDA-approved test.

read more | 6 comments | 2035 reads

Novel Role of the NEDD9 Gene in Early Stages of Breast Cancer
By Dross at 2013-01-15 04:28

PHILADELPHIA, PA (January 14, 2013)—Breast cancer is the second leading cause of cancer deaths among women in the United States. Many of these deaths occur when there is an initial diagnosis of invasive or metastatic disease. A protein called NEDD9—which regulates cell migration, division and survival—has been linked to tumor invasion and metastasis in a variety of cancers. Researchers at Fox Chase Cancer Center have now shown that NEDD9 plays a surprising role in the early stages of breast tumor development by controlling the growth of progenitor cells that give rise to tumors.

read more | 1445 reads

Blocking cell surface expression of EGFR
By Dross at 2013-01-15 02:59

Shutting down a specific pathway in cancer cells appears to improve the ability of common drugs to wipe those cells out, according to new research from scientists at Fox Chase Cancer Center, published in the January issue of Cancer Discovery.

"Ideally, this research will eventually enable scientists to find drugs that disrupt this pathway and boost the impact of current therapies," says Igor Astsaturov, MD, PhD, Attending Physician in the Department of Medical Oncology at Fox Chase. "That's the long-term plan."

read more | 1 comment | 1684 reads

How to register
By Dross at 2013-01-12 14:17

Due to hacking attempts, we've been forced to close automatic registrations. If you would like to join our community, please use the contact us form and request access. While this might sound archaic, I believe it will give us a more complete understanding of your current situation. It's human, if you will.  Regards, Dr. Ross 

Update: Registrations have been re-instated. Please include your disease state in your profile, and refrain from using your full name.

2210 reads

Simply finding a mutation
By gdpawel at 2013-01-07 22:27

The idea of simply finding a mutation and then pick an appropriately targeted drug seems like a nice idea. However, not every key that looks like it will fit a lock will actually turn it. The same is likely to be the case with targeted drugs. There are numerous common mutations in various tumor types, but they don't know that all those mutations are going to turn out to be relevant, as many of them are essentially bystanders.

read more | 2 comments | 2112 reads

Stem cell transplantation in Rhesus macaques treated with chemotherapy restores fertility
By admin at 2012-12-01 19:39

In what may provide new hope for young cancer patients. Spermatogonial stem cells have been harvested from rhesus macaques, frozen, and reimplanted after a typical dose of chemotherapy was administered to the primate patients. The stem cells were able to implant and generate functional sperm.

read more | 1 comment | 1992 reads

Clinical trial delivers results in leukemia patients
By Dross at 2012-11-30 21:21

Two researchers from the Huntsman Cancer Institute have published results for a recent clinical trial using the drug ponatinib for the treatment of chronic myelogenous leukemia in patients that were refractory to Gleevec and other standard treatments for Philadelphia chromosome positive hematological neoplasms.

Conducted at five cancer centers, this phase one trial demonstrated that ponatinib was highly active in patients with CML and Ph++ ALL who were resistant to approved tyrosine kinase inhibitors.

read more | 6 comments | 2605 reads


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