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Cancer-associated long noncoding RNA regulates pre-mRNA splicing
By Dross at 2010-09-28 00:34
 

CHAMPAIGN, Ill. — Researchers report this month that MALAT1, a long non-coding RNA that is implicated in certain cancers, regulates pre-mRNA splicing – a critical step in the earliest stage of protein production. Their study appears in the journal Molecular Cell.

read more | 1165 reads

Blood test accurately predicts death from prostate cancer up to 25 years in advance
By Dross at 2010-09-15 21:45
 

NEW YORK, September 14, 2010 – A blood test at the age of 60 can accurately predict the risk that a man will die from prostate cancer within the next 25 years, according to researchers at Memorial Sloan-Kettering Cancer Center, in New York, and Lund University, in Sweden. The findings, published today online in the British Medical Journal, could have important implications for determining which men should be screened after the age of 60 and which may not benefit substantially from continued prostate cancer screening.

read more | 2150 reads

Watercress may turn off breast cancer signal
By Dross at 2010-09-15 05:32
 

New scientific research from the University of Southampton has revealed that a plant compound in watercress may have the ability to suppress breast cancer cell development by 'turning off' a signal in the body and thereby starving the growing tumour of essential blood and oxygen. The research, unveiled at a press conference today (14 September 2010), shows that the watercress compound is able to interfere with the function of a protein which plays a critical role in cancer development.

read more | 2143 reads

Muscle Wasting In Cancer Does Not Spare The Heart
By Dross at 2010-09-11 03:02
 

The wasting disease associated with some cancers that is typically seen affecting skeletal muscles can also cause significant damage to the heart, new research in mice suggests.

Before now, cachexia, characterized by muscle wasting and dramatic weight loss, was believed to spare the heart. But an Ohio State University study showed that the condition reduces heart function and changes the heart muscle structure in mice with colon cancer.

read more | 1487 reads

'Basal-like' breast cancer does not originate from basal stem cells
By Dross at 2010-09-03 04:36
 

New research uncovers a case of mistaken identity that may have a significant impact on future breast cancer prevention and treatment strategies. The study, published by Cell Press in the September 3rd issue of the journal Cell Stem Cell, suggests that despite their "stem cell-like" characteristics, most aggressive breast tumors are not derived from normal mammary gland stem cells.

read more | 5 comments | 1818 reads

For the first time, researchers identify and isolate adult mammary stem cells in mice
By Dross at 2010-09-02 22:43
 

identify

SEATTLE – For the first time, researchers at Fred Hutchinson Cancer Research Center have identified and isolated adult mammary stem cells in mice. Long-term implications of this research may include the use of such cells to regenerate breast tissue, provide a better understanding of the role of adult stem cells in breast cancer development, and develop potential new targets for anti-cancer drugs.

read more | 1528 reads

New Recommendations Issued for Use of Cetuximab in Colon Cancer Therapy
By Dross at 2010-07-17 00:47
 

In a report published in the July 2010 issue of the American Society for Clinical Oncology Post, new recommendations on the use of the drug cetuximabtermterm have been issued after officials halted enrollment in a phase III clinical trial in patients with spread of colon cancer into regional lymph nodes whose tumors had been surgically removed.

Based on earlier studies, cetuximab is now indicated for treatment of patients with advanced colorectal cancer whose tumors do not have a mutation in the KRAS gene.

read more | 4 comments | 1888 reads

Anti-cancer effects of broccoli ingredient explained
By Dross at 2010-07-14 03:45
 

Light has been cast on the interaction between broccoli consumption and reduced prostate cancer risk. Researchers writing in BioMed Central's open access journal Molecular Cancer have found that sulforaphane, a chemical found in broccoli, interacts with cells lacking a gene called PTEN to reduce the chances of prostate cancer developing.

read more | 2107 reads

How prostate cancer packs a punch
By Dross at 2010-07-14 03:43
 

LA JOLLA, Calif., July 12, 2010 – Some types of prostate tumors are more aggressive and more likely to metastasize than others. Nearly one-third of these aggressive tumors contain a small nest of especially dangerous cells known as neuroendocrine-type cells. More rarely, some aggressive prostate tumors are made up entirely of neuroendocrine-type cells. The presence of neuroendocrine-type cancer cells is associated with a poor prognosis, but spotting these rare cells can be like finding a needle in a haystack.

read more | 1160 reads

Study makes exciting progress in elucidating the mechanisms of bortezomib in lymphoma
By Dross at 2010-07-14 03:41
 

A new study by researchers from the John Theurer Cancer Center at Hackensack University Medical Center sheds light on how bortezomib (VELCADE®), the first in a new class of cancer drugs known as proteasome inhibitors, works in mantle cell lymphomaterm. The study also provides preliminary evidence for which patients might benefit most from bortezomib. Additionally, researchers demonstrate that biomarkers – the genes and proteins that indicate biological processes – might help guide the selection of patients for specific clinical trials and speed-up the development of targeted cancer drugs.

read more | 1372 reads

Radiation device allows for targeted breast radiation to control cancer
By Dross at 2010-07-14 03:40
 

A new study of breast cancer patients at the Moores UCSD Cancer Center and the Arizona Oncology Services shows that after almost two years, the radiation given with the Strut-Adjusted Volume Implant (SAVI™) controls the rate of cancer and may reduce the complications seen with alternate types of brachytherapy. This study also demonstrates the accuracy and flexibility of the device to maximize the dose to the target tissue and minimize the exposure of healthy surrounding tissue and organs.

read more | 1542 reads

Prediction tool helps estimate local recurrence in patients with noninvasive breast cancer
By Dross at 2010-07-14 03:36
 

NEW YORK, July 13, 2010 – The decision regarding treatment following breast-conserving surgery for patients diagnosed with ductal carcinomaterm in-situ (DCIS) has long been an area of discussion and confusion for patients and physicians alike. While the mortality rates for DCIS remain low, the risk of local recurrence in the breast is high. Standard treatments following surgery include radiation therapy and hormone treatment.

read more | 1519 reads

Smoking influences gene function, scientists say
By Dross at 2010-07-14 03:34
 

SAN ANTONIO, July 13, 2010 – In the largest study of its kind, researchers at the Southwest Foundation for Biomedical Research (SFBR) have found that exposure to cigarette smoke can alter gene expression -- the process by which a gene's information is converted into the structures and functions of a cell. These alterations in response to smoking appear to have a wide-ranging negative influence on the immune system, and a strong involvement in processes related to cancer, cell death and metabolism.

read more | 5 comments | 1745 reads

High-risk prostate cancer associated with significantly lower bone mineral content loss
By Dross at 2010-07-14 03:32
 

Men with prostate cancer lose significantly less bone mineral content (BMC) as they age than men who are free of the disease, according to research in the July issue of BJUI. The findings are important because loss of BMC can play a key role in the development of fragile bones, fractures and osteoporosis.

read more | 1 comment | 1711 reads

A new cancer vaccine starves tumours of blood
By Dross at 2010-05-24 23:10
 

 

 

A new cancer vaccine starves tumours of blood

A DNA-vaccine that restricts the supply of blood to tumours has been developed by scientists at the Swedish medical university Karolinska Institutet. The vaccine slows the growth of breast cancer tumours in mice.

read more | 1052 reads

 
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