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stem cells
Stem cells develop best in 3D
By admin at 2012-11-25 18:45

Stem cells are responsible for tissue growth and tissue repair after injury. Therefore, the discovery that these vital cells grow better in a three-dimensional environment is important for the future treatment of disease with stem cell therapy.

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Reprogramming adult cells into iPS cells using adenoviruses instead of retroviruses
By gdpawel at 2008-10-12 01:38

Researchers Report Stem Cell Advance

By Jeffrey Perkel
HealthDay Reporter
September 25, 2008

Researchers report that they have sidestepped a major technical hurdle in the generation of pluripotent stem cells from adult cells.

A team of Boston scientists developed a way to generate induced pluripotent stem cells (iPS) -- which are functionally similar to embryonic stem cells, but which can be produced from adult cells, rather than via the creation or destruction of an embryo -- more safely than ever.

Should the findings, which involved mouse cells, be repeated with humans, they could pave the way for using iPS to delve into the biology of a wide range of genetic diseases. Longer term, they could lead to patient-specific stem-cell therapies.

read more | 3 comments | 4077 reads

Adult Stem Cell Treatment Ready for Human Testing?
By gdpawel at 2008-10-12 01:25
Adult Stem Cell Treatment Ready for Human Testing?
by Marty Graham
Wired Magazine
August 29, 2008

    Doctors might soon be able to regrow injured muscles, tendons and bones without invasive surgery, simply by injecting a person's own stem cells into the site of an injury. Veterinarians are already doing it with injured horses, and research into human applications is well under way.

    The National Institutes for Health seem to think regenerating human muscle and bone using a person's own adult stem cells is nearly ready for prime time. The NIH announced to its staff that it's creating a bone marrow-stem cell transplant center within the National Institute for Arthritis and Musculoskeletal and Skin Diseases.

read more | 2 comments | 2847 reads

Consent issues restrict stem-cell use
By Dross at 2008-07-31 22:56

Stanford University is to tell its researchers that around one-quarter of the human embryonic stem-cell lines eligible for US government funding are now off-limits because of ethics concerns.

The institute, in Palo Alto, California, is concerned that some of the women who donated the embryos for these stem-cell lines did not give informed consent for the lines to be used in research. Johns Hopkins University in Baltimore, Maryland, has decided to reconsider lines individually as researchers express an interest in using them.

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Advances in imrpoving the efficiency of induced pluripotent stem cells
By Dross at 2008-07-03 21:26

The American poet E. E. Cummings lionized the singular 'i', creating a persona standing apart from the crowd and, without power, scoffing at pretentious authority. Capitalist marketeers and scientists alike have repopularized the poetic 'i', perhaps innocently, in iMac and iPhone, Wii and RNAi. Biology's latest 'i' acronym is iPS cells, for induced pluripotent stem cells — antithetically one of the most potent of all cell types1. To produce iPS cells, drab adult cells are induced into a rejuvenated, embryonic stem (ES)-cell-like state by a puissant cocktail of just four genes — a process known as direct reprogramming. But exactly how this remarkable process works, and why it is so inefficient, has been a mystery. On page 49 of this issue, Mikkelsen et al.2 explain why many of the cells get stuck in a woolly intermediate state during reprogramming, and show how to put them back on the path to pluripotency (the ability of a cell to differentiate into all adult cell types).

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BRCA1 mutation linked to breast cancer stem cells
By Dross at 2008-02-01 00:22

A new study may explain why women with a mutation in the BRCA1 gene face up to an 85 percent lifetime risk of breast cancer.

Researchers from the University of Michigan Comprehensive Cancer Center found that BRCA1 plays a role in regulating breast stem cells, the small number of cells that might develop into cancers.

The study, in mice and in human breast cancer cells, found that BRCA1 is involved in the stem cells differentiating into other breast tissue cells. When BRCA1 is missing, the stem cells accumulate unregulated and develop into cancer.

“Our data suggest that an important reason women with BRCA1 mutations get breast cancer is that BRCA1 is directly involved in the regulation of normal breast stem cells. In these women, loss of BRCA1 function results in the proliferation of breast stem cells. Since we believe that breast cancer may originate in these cells, this explains why these women have such a high incidence of breast cancer,” said senior study author Max S. Wicha, M.D., Distinguished Professor of Oncology and director of the U-M Comprehensive Cancer Center.

read more | 1203 reads

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