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liver
Targeting nerve growth factor may cure liver cancer
By Dross at 2007-09-20 00:47
 

Nerve growth factor (NGF), as the name says, is an essential peptide factor for the growth and differentiation of neuronal cells. Therefore we can imagine that this growth factor is important for the nervous system including brain. But a recent scientific report published in the October 7 issue of the World Journal of Gastroenterology tells us another surprising and exciting discovery about this growth factor: NGF is positively related with liver cancer, the No.2 killer among all kinds of cancers in the world.

This research was collaboration among scientists from National Research Council of Italy, Marino Hospital in Rome, Regina Elena Cancer Institute in Rome, and University of Rome. This fruitful collaboration was under the leadership of Dr Annalucia Serafino, a talented biologist who has made her well-recognized reputation in cancer research and hepatitis C virus research. She is holding a senior researcher position in the national research council in Rome, which plays a similar role as the National Institutes of Health in the United States.

read more | 2117 reads

Antibody retards growth and induces death in liver cancer cells
By Dross at 2007-07-11 22:52
 

PITTBURGH, July 11 – Researchers from the University of Pittsburgh School of Medicine report a significant new advance in the search for an effective treatment for human liver cancer in the July issue of Molecular Cancer Therapeutics. Using a newly available monoclonal antibodyterm, they demonstrated significant reductions in tumor cell proliferation and survival in human and mouse hepatocellular cancer (HCC) cell lines. According to the researchers, this finding has significant implications not only for the treatment of liver cancer but for a number of different types of cancer.

Most cases of HCC are secondary to either a viral hepatitis infection or cirrhosis of the liver. Despite recent advances, it remains a disease of grim prognosis due to the poorly understood mechanism of how the disease originates and spreads. Most patients live only a short time after diagnosis.

read more | 4035 reads

Ablation procedure proves safe, effective and fast
By Dross at 2007-06-29 22:21
 

Multiple-electrode radiofrequency ablation is a safe and effective way of treating patients with liver cancer that can be completed in less time than current ablation techniques, according to a recent study conducted by researchers at the University of Wisconsin in Madison.

“One of the biggest limitations of current radiofrequency ablation techniques is the inability to effectively treat large tumors” said Paul Laeseke, PhD, lead author of the study. “Current radiofrequency ablation systems can only power one electrode and create relatively small ablation zones,” Dr. Laeseke said. Large tumors are treated by sequentially overlapping the small ablation zones--a technique that is both complicated and time consuming,” he said.

read more | 1218 reads

Correlating Gene Expression with CT Scan imaging
By Dross at 2007-05-22 22:15
 

Researchers at the University of San Diego, in colloboration with researchers at Stanford, have created a new procedure correlating images of cancerous liver tissue with gene expression patterns,  which may some day allow physicians to view a CT image of a cancer tumor and discern its genetic activity. The study, designed to help doctors obtain the molecular details of a specific tumor or disease without having to do an invasive biopsy procedure, will be published online on May 21 in Nature Biotechnology.

According to principle investigator Michael Kuo, M.D., assistant professor of interventional radiology at UCSD, the study represents the convergence of two developing fields of medical research: the mapping of the human genome and advances in diagnostic imaging.

read more | 1 comment | 2989 reads

Mailman School of Public Health researchers report blood DNA can be early predictor of liver cancer
By Dross at 2007-04-16 23:12
 

esearchers at Columbia University’s Mailman School of Public Health have discovered a means for early detection of liver cancer. Using DNA isolated from serum samples as a baseline biomarker, the scientists examined changes in certain tumor suppressor genes that have been associated with the development of liver carcinomas. This is the first study to prospectively examine potential biomarkers for early detection of liver cancer in high-risk populations, including those with chronic hepatitis B and C virus infections.

Since most hepatocellular or liver carcinomas (HCC) are diagnosed at an advanced and usually fatal stage, the development of screening methods for early detection is critical. HCC is one of the most common and rapidly fatal human malignancies. Worldwide, the almost 500,000 new cases and nearly equivalent number of fatalities illustrates the lack of effective therapeutic alternatives for this disease.

read more | 1172 reads

Liver Cancer Basics
By Dross at 2007-02-19 06:55
Definition of liver cancer: Primary liver cancer is cancer that forms in the tissues of the liver. Secondary liver cancer is cancer that spreads to the liver from another part of the body.


Estimated new cases and deaths from liver and intrahepatic bile duct cancer in the United States in 2007:


New cases: 19,160
 
Deaths: 16,780

 

read more | 50739 reads

Study shows liver an excellent target for cancer gene therapy using viral vectors
By Dross at 2007-02-15 06:21
 

    A featured paper in the February 14 issue of Nature Cancer Gene Therapy demonstrates that cancer cells in the liver are excellent targets for gene therapy using adenoviral vectors, based upon a fundamental new understanding of the differences between cancerous and normal liver cells. The findings signal a new way to treat cancers that have spread to the liver, such as metastaticterm cancers of the colon and breast. The research team, led by Tony Reid, M.D., Ph.D., of the Moores Cancer Center at University of California, San Diego (UCSD), reports that in normal liver cells there is only one receptor or doorway the vector uses to enter the cell. This doorway is located at the base of normal liver cells, hidden from the blood vessels.

read more | 1188 reads

Nexavar shown to significantly extend survival for patients with advanced liver cancer
By Dross at 2007-02-13 21:52
 

Bayer Pharmaceuticals Corporation (NYSE: BAY) and Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX) today announced that an independent data monitoring committee (DMC) has reviewed the safety and efficacy data from the companies' pivotal Phase 3 trial in patients with advanced hepatocellular carcinomaterm (HCC), or primary liver cancer. Based on this planned interim analysis, the DMC has concluded that the trial met its primary endpoint resulting in superior overall survival (OS) in those patients receiving Nexavartermterm (sorafenibterm) tablets versus those patients receiving placebo.

read more | 1668 reads

Multiple Cancer Types treated with Photodynamic Therapy for Tumor Ablation
By HCat at 2007-01-09 03:04
 

    Photodynamic therapy (PDT) is more than 25 years old, yet this cancer therapy is now becoming more widely used in multiple cancer treatment areas. PDT uses an injectable drug (usually photofrin) that is light sensitive to certain wavelengths. When this photosensitizer is hit with light at the particular wavelengths, a chemical-light reaction occurs in which numerous oxygen radicals are formed. These oxygen radicals cause damage and death to cells, inducing apoptosis and necrosis to the surrounding tissue while also initiating the immune and inflammation response within the body. To specify where the damage occurs, the light source is inserted into a fiber optic wire within a needle. The needle is then guided to the site of the cancer through various imaging techniques such as computed tomographic (CT) imaging or magnetic resonance imaging (MRI).

read more | 2435 reads

New Compound May Protect Against Liver Cancer, February 15, 2006 News Release - National Institutes of Health (NIH)
By admin at 2006-11-22 10:49
 

Researchers have identified a new compound called CDDO-Im that protects against the development of liver cancer in laboratory animals.

 

The compound appears to stimulate the enzymes that remove toxic substances from the cells, thereby increasing the cell's resistance to cancer-causing toxins. The National Institute of Environmental Health Sciences and the National Cancer Institute, agencies of the federal National Institutes of Health, provided funding to researchers at the Johns Hopkins Bloomberg School of Public Health for the two-year study.

read more | 1047 reads

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