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therapeutic window
Dichloroacetate: Panacea or Problematic?
By HCat at 2007-02-08 07:06
 

    Dichloroacetate (DCA) has hit the headlines with a splash recently being held as a cheap cure for cancer. The recent article in Cancer Cell is very intriguing in that it presents DCA as promoting apoptosis and inhibiting growth selectively in cancer cells while leaving healthy cells alone. The article also presents data showing it is not toxic to the liver.

However, there are a few perspectives of this compound that should be included in the public’s mind.

read more | 1 comment | 8004 reads

Reasons Why Cancer Drug Discovery is so Difficult
By HCat at 2007-01-31 23:56
 

    In the perspective article in Nature Reviews Drug Discovery, the authors discuss the challenges facing drug discovery as intricate and numerous. They present a broad picture of drug discovery as three parts pertaining to targets, drugs, and patients. Targets for drug discovery are broken down into two classes, each of which is either essential or non-essential. Essential targets for drug discovery are targets that have essential function within all cells or a specific cell type. That means that the cell has to have this function operating or it will die. Non-essential targets are targets whose function can be lost and the cell will still survive. This concept can also be applied in terms of tissues as a target such as in breast tissue which is considered a non-essential tissue for life. Drugs that inhibit or block essential functions are likely to have narrow therapeutic windows. That is the drugs beneficial dose range is likely to be small before it becomes toxic such as 5-FUterm. 5-FU relies on the principle that cancer cells should be faster growing since they are growing out of control. 5-FU inhibits DNA synthesis, an essential function. Slow growing cells are not as affected as fast growing cells from 5-FU. This therapeutic windowterm is narrow and the consequences or side effectsterm of the narrow window is that 5-FU affects some of the naturally fast growing cells in the body, which is why hair loss is a common side-effect in 5-FU treatment.

read more | 3980 reads

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