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polymorphisms
Polymorphisms in One Gene May Play Role in Aggressive Nature of Esophageal Adenocarcinoma (EAC)
By HCat at 2007-03-05 06:33
 

    Researchers from M.D. Anderson Cancer Center, TX have published in the Journal of Clinical Oncology an analysis of esophageal adenocarcinomaterm (EAC) and Barrett’s esophagus (BE) tissue samples in order to understand a single base-pair change in a gene encoding Cycling D1.

    EAC has become more prevalent with a poor overall survival rate. The need for a new molecular markers for risk, diagnosis, and therapeutic targets may now be meet in the gene encoding the protein Cyclin D1 (CD1). CD1 is a protein that plays a crucial role in the cell cycle, allowing cells to go through the process of division. The cell cycle has become unrestricted, and cells continuously divide with uncontrolled growth in cancer cells.

read more | 2167 reads

Reasons Why Cancer Drug Discovery is so Difficult
By HCat at 2007-01-31 23:56
 

    In the perspective article in Nature Reviews Drug Discovery, the authors discuss the challenges facing drug discovery as intricate and numerous. They present a broad picture of drug discovery as three parts pertaining to targets, drugs, and patients. Targets for drug discovery are broken down into two classes, each of which is either essential or non-essential. Essential targets for drug discovery are targets that have essential function within all cells or a specific cell type. That means that the cell has to have this function operating or it will die. Non-essential targets are targets whose function can be lost and the cell will still survive. This concept can also be applied in terms of tissues as a target such as in breast tissue which is considered a non-essential tissue for life. Drugs that inhibit or block essential functions are likely to have narrow therapeutic windows. That is the drugs beneficial dose range is likely to be small before it becomes toxic such as 5-FUterm. 5-FU relies on the principle that cancer cells should be faster growing since they are growing out of control. 5-FU inhibits DNA synthesis, an essential function. Slow growing cells are not as affected as fast growing cells from 5-FU. This therapeutic windowterm is narrow and the consequences or side effectsterm of the narrow window is that 5-FU affects some of the naturally fast growing cells in the body, which is why hair loss is a common side-effect in 5-FU treatment.

read more | 4021 reads

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