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Breast Cancer
Screening MRI allows detection of more breast cancers in high-risk women
By Dross at 2007-08-01 08:25

OAK BROOK, Ill. – Magnetic resonance imaging (MRI) enables radiologists to accurately identify tumors missed by mammography and ultrasound, according to a multicenter study comparing the three screening methods in women at high-risk for breast cancer. The findings of the study appear in the August issue of the journal Radiology.

“Women at high risk for breast cancer can benefit from undergoing screening MRI,” said the study’s lead author, Constance Dobbins Lehman, M.D., Ph.D., professor of radiology at the University of Washington School of Medicine and director of breast imaging at the Seattle Cancer Care Alliance. “Of all the breast imaging tools we have currently available, MRI is clearly the best at detecting cancer.”

read more | 1638 reads

Support groups don't extend survival of metastatic breast cancer patients, Stanford study finds
By Dross at 2007-07-23 22:50

TANFORD, Calif. - A new study from a team of Stanford University School of Medicine researchers led by David Spiegel, MD, shows that participating in support groups doesn't extend the lives of women with metastaticterm breast cancer. The results differ from oft-cited previous findings by Spiegel that showed group psychotherapy extended survival time.

The newest research did, however, confirm that support groups improved quality of life for the participants, and showed a survival benefit for a subgroup of patients with an aggressive form of breast cancer.

"We didn't confirm earlier observations that group psychotherapy extends overall survival for women with metastatic breast cancer, but we did again show a positive effect on mood and pain," said Spiegel, professor and associate chair of psychiatry and behavioral sciences. "I still very much believe this type of therapy is crucial to cancer care."

read more | 1 comment | 1137 reads

Src inhibitors may prove beneficial in breast cancer therapy
By Dross at 2007-07-13 17:03

Estrogen, which binds estrogen receptor alpha (ER-alpha), is a risk factor for breast cancer development. However, one-third of new breast cancers lack detectable ER-alpha. These ER-alpha–negative cancers are more aggressive and have a worse prognosis than do ER-alpha–positive breast cancers, and have been thought to be estrogen independent. In a study appearing online on July 12 in advance of publication in the August print issue of the Journal of Clinical Investigation, Joyce Slingerland and colleagues from the University of Miami shed further light on the mechanisms regulating ER-alpha expression levels during breast cancer.

read more | 3 comments | 1030 reads

Exercise helps breast cancer survivors
By Dross at 2007-07-13 00:41

COLUMBUS, Ohio – A study of more than 500 breast cancer survivors shows that it’s never too late to reap the benefits of an exercise program.

            The study, published in a recent issue of the Journal of Cancer Survivorship, found that breast cancer survivors who pursued physical activity during and after treatment reported an improved quality of life, including less fatigue and pain.

            “We wanted to investigate why some breast cancer survivors come out of treatment just fine and go on about their lives, while others have problems with symptoms like fatigue and pain that limit their quality of life,” says first author Catherine M. Alfano, a researcher in the Cancer Control program at the Ohio State University Comprehensive Cancer Center. “We want to try to help those survivors improve their quality of life and lead healthy, productive lives.”

read more | 1050 reads

Stem cells used to build breast tissue after mastectomy
By Dross at 2007-07-12 19:33

Scientists in Japan claim to be able to increase the size of a woman's breasts using fat and stem cells. The technique uses fat from the stomach or thigh which is then enriched with stem cells before being injected. It is hoped the method could prove a more natural-looking alternative to artificial implants filled with salt water or silicone. But plastic surgeons working in Britain have greeted news of the technique with "extreme caution." Kotaro Yoshimura, a surgeon at the Tokyo University medical school, said more than 40 patients had been treated.


[via BBC NEWS | Health | Stem cells used to boost breasts]:

2014 reads

Study finds western-style 'meat-sweet' diet increases risk of breast cancer in postmenopausal women
By Dross at 2007-07-10 18:16

PHILADELPHIA – A new study finds that the more “western” the diet -- marked by red meat, starches and sweets -- the greater the risk for breast cancer among postmenopausal Chinese women. According to researchers who conducted the analysis at Fox Chase Cancer Center in Philadelphia, Harvard University, Shanghai Cancer Institute, and Vanderbilt University, the findings mark the first time a specific association between a western diet and breast cancer has been identified in Asian women.

The study, published in the July issue of Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research, is the latest set of findings derived from the Shanghai Breast Cancer Study, conducted in the 1990s by Wei Zheng, M.D., Ph.D., M.P.H, and colleagues at Vanderbilt University. The Fox Chase researchers identified dietary habits among women in the study based on their reported eating habits, classifying them as either “meat-sweet” or “vegetable-soy” eaters.

read more | 855 reads

Link between immune system and mammary gland could shed new light on breast cancer
By Dross at 2007-07-06 13:42

Scientists at the University of Cambridge have published new research today (5 July) in the journal Development showing an unexpected link between a fundamental part of the immune system and the cells that produce milk in the breast during lactation.

The researchers, funded by the Biotechnology and Biological Sciences Research Council (BBSRC), found that cytokines, which have a central role in immune response, are used in the breast to promote the production of milk producing cells. The finding has implications for understanding breast cancer as cells that respond incorrectly to cytokine signalling can grow out of control and become cancerous.

read more | 897 reads

Maxygen Initiates Phase IIa Clinical Trial of MAXY-G34 in Breast Cancer Patients
By Dross at 2007-07-03 10:53

Maxygen, Inc. (NASDAQ:MAXY) today announced that it has initiated a phase IIa trial to evaluate the efficacy, safety and tolerability of MAXY-G34 in the treatment of chemotherapyterm-induced neutropenia. MAXY-G34 is a novel pegylated granulocyte colony stimulating factor (PEG-GCSFterm) shown in preclinical and Phase I studies to have novel and potentially superior properties compared to the current PEG- GCSF therapy.

"Patients and physicians have limited options for treatment of neutropenia," said Russell Howard, chief executive officer of Maxygen. "With MAXY-G34, we hope to expand those options and improve the outcome for many chemotherapy patients. During this first Phase II trial we will begin to learn more about how our drug might play a role in the large, undifferentiated GCSF market."

read more | 908 reads

Researchers discover method for identifying how cancer evades the immune system
By Dross at 2007-07-03 09:58

One of the fundamental traits of a tumor - how it avoids the immune system - might become its greatest vulnerability, according to researchers from the University of Southern California. Their findings, demonstrated in human breast and colorectal cancers, indicate that a technique for determining a tumor�s �immune signature, could be useful for diagnosing and treating specific cancers.

In the July 1 issue of Clinical Cancer Research, a publication of the American Association for Cancer Research, the researchers describe a means for determining which genes have been altered in a tumor to allow it to evade the body�s natural defenses. In time, the researchers believe such analysis could become a standard practice in cancer diagnosis and treatment.

read more | 741 reads

MRI plus X-ray mammography doubles breast cancer detection in women at high risk
By Dross at 2007-07-02 15:16

For women at high risk of breast cancer, use of magnetic resonance imaging (MRI) plus X-ray mammography for screening will detect more breast cancers than mammography alone, a new technology assessment has found. But the number of false positives —indicating a problem where none exists — will rise significantly also.

MRI is an imaging procedure that uses a magnetic field and pulses of radio wave energy to make images of organs and structures inside the body. The report aimed to determine whether the combination of MRI and mammography was more accurate than mammography alone in finding breast cancer.

read more | 546 reads

New adjuvant treatments for breast cancer prove cost-effective
By Dross at 2007-06-25 21:05

New adjuvant treatments for breast cancer are cost-effective at improving survival, according to two new studies. Published in the August 1, 2007 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the two studies looked at the cost-effectiveness of different drugs for the management of adjuvant therapies for early breast cancer. In a Canadian economic study of estrogen receptor positive breast cancers, switching from tamoxifen to the oral steroidal aromatase inhibitor exemestane (trade name: Aromasin) extended disease free survival at a minimal cost per person. In another of study of human epidermal growth factor receptor 2 (HER2)-positive breast cancer, the addition of the anti-HER2 receptor monoclonal antibodyterm, trastuzumab (trade name: Herceptin), is projected to improve life expectancy at a relatively low cost.

read more | 1 comment | 1811 reads

Pregnancy nausea/vomiting may indicate lower risk of breast cancer
By Dross at 2007-06-25 08:10

It may not seem so at the time, but women who suffer through morning sickness during their pregnancies actually may be fortunate.

Those women may have a 30 percent lower risk of developing breast cancer later in life than mothers-to-be who experience nine nausea-free months, a new study by epidemiologists at the University at Buffalo suggests.

“Although the exact mechanism responsible for causing nausea and vomiting during pregnancy has yet to be pinpointed, it likely is a result of changing levels of ovarian and placental hormone production, which may include higher circulating levels of a hormone called human chorionic gonadotropin,” said David Jaworowicz, Jr., first author on the study.

read more | 650 reads

Software enhancement of breast MRI scans help radiologists reduce false positives
By Dross at 2007-06-24 06:56

- Using commercially available software to enhance breast scans done by magnetic resonance imaging (MRI) reduces the number of false positive identifications of malignant tumors and the subsequent need for biopsies, according to a new study.

Teresa Williams, M.D., and colleagues at the Seattle Cancer Care Alliance and the University of Washington Medical Center did a retrospective examination of 154 breast lesions deemed suspicious by radiologists that were only visible on MRI and that had been biopsied under MRI guidance. They compared the findings and recommendations made by radiologists at the time to new findings using computer-aided enhancement (CAE) software to enhance and evaluate the visible response to contrast agents absorbed by breast tissue.

read more | 687 reads

New Adjuvant Treatments for Breast Cancer Prove Cost-
By Dross at 2007-06-21 01:35

New Adjuvant Treatments for Breast Cancer Prove Cost-
New adjuvant treatments for breast cancer are cost-
effective at improving survival, according to two new
studies. Published in the August 1, 2007 issue of CANCER, a
peer-reviewed journal of the American Cancer Society, the
two studies looked at the cost-effectiveness of different
drugs for the management of adjuvant therapies for early

read more | 1496 reads

Family structure size could affect breast cancer risk prediction accuracy for BRCA gene testing
By Dross at 2007-06-20 04:28

Researchers have found that the probability of the breast cancer gene mutation BRCA among women with a history of breast cancer is greater when the number of older, female relatives in the family is smaller, according to a study in the June 20 issue of JAMA. This finding may challenge the accuracy of some breast cancer prediction models, which may not take family structure into account.

“Germline BRCA1 or BRCA2 gene mutations significantly increase a woman’s risk of breast cancer (50 percent - 85 percent) and ovarian cancer (16 percent - 50 percent),” the authors write. “Documented efficacy of screening and risk reduction interventions provides evidence for individualized risk management advice, making genetic cancer risk assessment (GCRA) a component of medically necessary care. Identifying appropriate candidates for GCRA is challenging.”

read more | 649 reads

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