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Breast Cancer
New target combined with Tamoxifen aids in ER-positive breast cancers
By Dross at 2013-07-09 00:44
Researchers have identified compounds used in some leukemiaterm treatments that may have an application towards ER positive breast cancer that is unresponsive to traditional treatments. 
The discovery was made at the Walter and Eliza Hall Institute. BH-3 mimetics were effective in treating aggressive oestrogen receptor-positive breast cancers when combined with the breast cancer drug tamixifen in preclinical models. Approximately 70 per cent of breast cancers are ER positive. 
read more | 1 comment | 6952 reads

Cancer stem cells the target in new clinical trial
By admin at 2013-07-03 22:47

Breast cancer often returns as chemotherapyterm is designed to target the tumor but not the cancer stem cells that are often the root of the disease.

It is this focus that drives a new clinical trial open now at Michigan Comprehensive Cancer Center and two more sites. Reparixin will be used in combination with standard chemotherapy.

read more | 4679 reads

Researchers reveal aggressive breast cancer's metastatic path
By Dross at 2013-01-17 05:22

Scientists at Weill Cornell Medical College have discovered the molecular switch that allows aggressive triple negative breast cancer cells to grow the amoeba-like protrusions they need to crawl away from a primary tumor and metastasize throughout the body. Their findings, published in Cancer Cell, suggest a novel approach for developing agents to treat cancer once it has spread.

read more | 1923 reads

Drop in breast cancer rates directly tied to reduced hormone therapy
By Dross at 2010-11-30 22:46

In a new UCSF study of more than 2 million mammogram screenings performed on nearly 700,000 women in the United States, scientists for the first time show a direct link between reduced hormone therapy and declines in ductal carcinomaterm in situ (DCIS) as well as invasive breast cancer. The researchers saw such a striking decrease, they believe they also have uncovered indirect evidence that hormones promote breast tumor growth.

read more | 2222 reads

Sporadic breast cancers start with ineffective DNA repair systems, Pitt researchers find
By Dross at 2010-11-30 05:13

 PITTSBURGH, Nov. 29 – Breast cancers that arise sporadically, rather than through inheritance of certain genes, likely start with defects of DNA repair mechanisms that allow environmentally triggered mutations to accumulate, according to researchers at the University of Pittsburgh School of Medicine, Magee-Womens Hospital of UPMC and the University of Pittsburgh Cancer Institute.

read more | 2020 reads

Lasofoxifene reduces breast cancer risk in postmenopausal osteoporotic women
By Dross at 2010-11-05 23:45

Lasofoxifene statistically reduced the overall risk of breast cancer, as well as ER positive invasive breast cancer in postmenopausal women with low bone density, according to a study published online in The Journal of the National Cancer Institute.

read more | 1515 reads

Rictor protein offers scientists a new molecular target for cancer therapies
By Dross at 2010-10-29 21:53

BOSTON – The discovery that a protein called Rictor plays a key role in destroying a close cousin of the AKT oncogene could provide scientists with a new molecular target for treating certain cancers, including breast cancer. Described in the September 2010 issue of the journal Molecular Cell, the study was led by scientists at Beth Israel Deaconess Medical Center (BIDMC).

read more | 1566 reads

Consuming vegetables linked to decreased breast cancer risk in African-American women
By Dross at 2010-10-14 01:57

(Boston) - Investigators from the Slone Epidemiology Center at Boston University School of Medicine (BUSM) have reported that African American women who consume more vegetables are less likely to develop estrogen receptor-negative breast cancer than women with low vegetable intake. The study results, published in the American Journal of Epidemiology, were based on data from the Black Women's Health Study (BWHS), a large follow-up study of 59,000 African American women from across the U.S. conducted by investigators at the Slone Epidemiology Center since 1995.

read more | 1620 reads

'Basal-like' breast cancer does not originate from basal stem cells
By Dross at 2010-09-03 04:36

New research uncovers a case of mistaken identity that may have a significant impact on future breast cancer prevention and treatment strategies. The study, published by Cell Press in the September 3rd issue of the journal Cell Stem Cell, suggests that despite their "stem cell-like" characteristics, most aggressive breast tumors are not derived from normal mammary gland stem cells.

read more | 5 comments | 1757 reads

For the first time, researchers identify and isolate adult mammary stem cells in mice
By Dross at 2010-09-02 22:43


SEATTLE – For the first time, researchers at Fred Hutchinson Cancer Research Center have identified and isolated adult mammary stem cells in mice. Long-term implications of this research may include the use of such cells to regenerate breast tissue, provide a better understanding of the role of adult stem cells in breast cancer development, and develop potential new targets for anti-cancer drugs.

read more | 1487 reads

Radiation device allows for targeted breast radiation to control cancer
By Dross at 2010-07-14 03:40

A new study of breast cancer patients at the Moores UCSD Cancer Center and the Arizona Oncology Services shows that after almost two years, the radiation given with the Strut-Adjusted Volume Implant (SAVI™) controls the rate of cancer and may reduce the complications seen with alternate types of brachytherapy. This study also demonstrates the accuracy and flexibility of the device to maximize the dose to the target tissue and minimize the exposure of healthy surrounding tissue and organs.

read more | 1490 reads

Prediction tool helps estimate local recurrence in patients with noninvasive breast cancer
By Dross at 2010-07-14 03:36

NEW YORK, July 13, 2010 – The decision regarding treatment following breast-conserving surgery for patients diagnosed with ductal carcinomaterm in-situ (DCIS) has long been an area of discussion and confusion for patients and physicians alike. While the mortality rates for DCIS remain low, the risk of local recurrence in the breast is high. Standard treatments following surgery include radiation therapy and hormone treatment.

read more | 1479 reads

Estrogen and Breast Tumor support
By Dross at 2010-03-10 00:17

MAYWOOD, Ill. -- A new study is providing insight into how estrogen fuels many breast cancers, and researchers say the findings could lead to new cancer-fighting drugs.


Researchers found that estrogen inhibits a protein called MLK3 that causes normal cell death. Blocking MLK3 leads to uncontrolled growth of cancer cells and resistance to chemotherapyterm.

Researchers from Loyola University Health System and three other centers reported the findings in the journal Cancer Research.

read more | 1923 reads

Prolactin blocks oncogene associated with poor prognosis in breast cancer
By Dross at 2010-02-03 23:52

(PHILADELPHIA) Researchers from the Kimmel Cancer Center at Jefferson have found a mechanism by which a hormone responsible for milk production blocks an oncogene that makes breast cancer more aggressive.

Publishing in the journal Cancer Research, the researchers discovered that prolactin, a pituitary hormone that normally stimulates breast development and milk production, in fact reduces levels of an oncogene called BCL6. The BCL6 protein has previously been shown to play a role in poorly differentiated breast cancer, which carries a poorer prognosis.

read more | 1479 reads

Novel drug combo improves breast cancer survival
By gdpawel at 2009-12-13 21:56

SAN ANTONIO -- Some women with very advanced breast cancer may have a new treatment option. A combination of two drugs that more precisely target tumors significantly extended the lives of women who had stopped responding to other medicines, doctors reported Friday.

It was the first big test of combining Herceptin and Tykerbterm. In a study of 300 patients, women receiving both drugs lived nearly five months longer than those given Tykerb alone.

read more | 1522 reads

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