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Brca
Gene for Breast Density and Cancer Risk correlated
By Dross at 2007-12-18 22:17
 

Tampa, FL (Sept. 14, 2007)  − Studying the DNA of 889 people, gene hunters at the Mayo Clinic and Moffitt Cancer Center have identified a region on chromosome 5p that is significantly associated with dense breast tissue, a known risk factor for breast cancer. The findings, published in this month’s issue of Cancer Research, a publication of the American Association for Cancer Research, suggest that genes that influence breast density could serve as a predictive marker for disease and provide a biological target for agents that may reduce breast cancer risk by reducing breast density.

read more | 1075 reads

Men unaware of their cancer risk when female relatives test positive for BRCA mutation
By Dross at 2007-12-14 21:45
 

Men whose mothers, sisters or daughters test positive for a cancer-causing gene mutation also have an increased risk of developing the disease but are unaware of that risk. That is the conclusion of a study at Fox Chase Cancer Center exploring how families communicate genetic test results.

Like their female relatives, fathers, sons or brothers can also harbor a mutation in the BRCA 1 or 2 genes. Male carriers of these mutations, more commonly called the “breast cancer genes,” face a 14 percent lifetime risk of developing prostate cancer as well as a 6 percent lifetime risk of developing breast cancer

read more | 3 comments | 1105 reads

BRCA Mutation Carriers Face Younger Diagnosis of DCIS
By HCat at 2007-03-03 09:22
 

    BRCA (BReast CAncer) genes are tumor suppressor genes that help stop normal cells from becoming cancers. BRCA2 is an integral component of the homologous recombination machinery, whereas BRCA1 is an E3 ubiquitin ligase involved in DNA repair and various other cellular processes. BRCA mutation carriers face an 85% lifetime risk of breast cancer and up to a 45% risk of ovarian cancer. BRCA1 and BRCA2 mutations account for less than 5% of diagnosed breast cancer. BRCA mutation carriers on average are diagnosed with invasive breast cancer about 10 years younger than a sporadic patient.

read more | 5 comments | 6447 reads

International study points to new breast cancer-susceptibility gene
By Dross at 2007-02-09 02:52
 

    A gene whose existence was detected only a couple of years ago may increase women's risk of breast cancer when inherited in a mutated form, and may contribute to prostate cancer as well, researchers at Dana-Farber Cancer Institute and colleagues in Finland report in a new study. The gene, known as PALB2, may play a role in only about 1 percent of breast cancer cases in the select population that was studied (Finnish women), but its discovery sheds light on the complex web of gene interactions that underlies the disease, say the authors of the study, which is being published by the journal Nature on its Web site, www.nature.com/nature, and lter in a print edition.

read more | 1506 reads

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