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Tumors bring their own support cells when forming metastases
By Dross at 2010-12-02 00:14


The process of metastasistermterm requires that cancer cells traveling from a primary tumor find a hospitable environment in which to implant themselves and grow. A new study from Massachusetts General Hospital (MGH) Cancer Center researchers finds that circulating tumor cells prepare this environment by bringing along from their original site noncancerous cells that support tumor growth. The report has been published online in PNAS Early Edition.

read more | 1 comment | 1489 reads

Dense tissue promotes aggressive cancers
By Dross at 2008-08-23 00:51

New research may explain why breast cancer tends to be more aggressive in women with denser breast tissue.

Breast cancer cells grown in dense, rigid surroundings step up their invasive activities, Vanderbilt-Ingram Cancer Center investigators report in the Sept. 9 issue of Current Biology.

The findings suggest a cellular mechanism for the correlation between human breast tissue density and tumor aggressiveness. Women with increased breast density on mammograms have an increased risk for both developing breast cancer and having breast cancers with invasive characteristics.

read more | 1236 reads

Catch of the day: zebrafish as a human cancer model
By Dross at 2008-07-31 22:50

Zebrafish are making big waves in the field of cancer research. The effect has been widespread and continues to gain speed as more and more cancer researchers ride the wave of zebrafish biology. This has been largely due to the development of transgenic and xenograft models of cancer, which recapitulate many aspects of different human cancers including lymphoblastic T-cell leukemiaterm, pancreatic cancer, melanoma and rhabdomyosarcoma. These models are already being utilized by academia and industry to search for genetic and chemical modifiers of cancer with success. The attention has been further stimulated by the amenability of zebrafish to pharmacological testing and the superior imaging properties of fish tissues that allow visualization of cancer progression and angiogenesis in live animals. This review summarizes the current zebrafish models of cancer and discusses their utility in human cancer research and future directions in the field

read more | 2277 reads

Scientists from the University of Navarra find 5 genes involved in the metastasis of breast tumours
By Dross at 2008-06-20 22:56

The identification of five genes involve in the metastasistermterm of breast tumours to the lung is the principal finding of a scientific team made up of two bodies from the University of Navarra, the Applied Medical Research Centre (CIMA) and the University Hospital of the University of Navarra.

Doctor Alfonso Calvo, researcher in the area of Oncology at the CIMA, led the work with the special collaboration of Doctor Ignacio Gil Bazo, cancer specialist from the University Hospital. The study made up a significant part of Mr Raúl Catena’s PhD thesis.

For this research, recently published in the scientific journal Oncogene, a transgenic mouse model which presented a greater tendency for developing metastasis was employed. The increase in what is known as the Vascular Endothelial Growth Factor (VEGFterm) in its mammary glands triggered profound changes in the tumoural structure, which enabled the malignant cells to leave the tumour and invade the lungs.

read more | 1713 reads

A gene for metastasis
By Dross at 2007-08-28 20:26

Colorectal cancer is one of the most prevalent cancers in the Western world. The tumor starts off as a polyp but then turns into an invasive and violent cancer, which often spreads to the liver. In an article recently published in the journal Cancer Research, Prof. Avri Ben-Ze’ev and Dr. Nancy Gavert of the Weizmann Institute’s Molecular Cell Biology Department reveal mechanisms that help this cancer metastasize.

In a majority of cases, colorectal cancer is initiated by changes in a key protein – beta-catenin. One of the roles of this protein is to enter the cell nucleus and activate gene expression. But in colorectal and other cancers, beta-catenin over-accumulates in the cell and inappropriately activates genes, leading to cancer.

read more | 3 comments | 1944 reads

Targeting sugar on blood vessels may inhibit cancer growth
By Dross at 2007-05-07 21:34

In a study that could point to novel therapies to prevent cancer spread, or metastasistermterm, researchers at the University of California, San Diego (UCSD) School of Medicine have targeted a sugar that supports blood vessel growth in the tumor. Their findings will be published in the May 7 on-line issue of Journal of Cell Biology.

Lung cancer is the most common cause of cancer death and an area where novel therapies to block metastasis are desperately needed, according to first author Mark M. Fuster, M.D., assistant professor in the Division of Pulmonary and Critical Care Medicine in UCSD’s Department of Medicine. Solid tumors need a network of blood vessels, or vasculature, in order to grow, and this vasculature drives metastasis. The research team, led by the paper’s principal investigator Jeffrey D. Esko, Ph.D., professor of Cellular and Molecular Medicine at UCSD, showed that modifying the action of heparan sulfate uniquely impacted the tumor vasculature, and in doing so, altered the growth rate of tumors prepared from lung carcinomaterm cells in the mice.

read more | 1904 reads

Metastasis, the real problem
By HCat at 2007-01-03 21:42

    Although this process is inefficient, metastasistermterm is the cause of 90% of human cancer deaths. Metastasis is a complex process where cells from the primary tumor migrate to distant organs and create new tumors. It has been shown in models that when cells from metastaticterm colon cancer are injected into mice, only 0.01% survive to create new sites. This article explores some of the steps involved in metastasis with a view about the role apoptosis plays in the events. Apoptosis is the orderly program by which cells die. As opposed to necrosis which is accidental cell death from acute injury, apoptosis is signaled to cells that have received cellular damage but can still function.

read more | 3684 reads

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