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CT and serum LDH shows promise as survival predictor for some metastatic melanoma patients
By Dross at 2013-04-17 18:05

Combining CT imaging findings with baseline serum lactate dehydrogenase levels is showing promise as a way to predict survival in patients with metastaticterm melanoma being treated with anti-angiogenic therapy.

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2 microRNAs promote spread of tumor cells
By Dross at 2008-01-29 01:10

(Philadelphia) – The more scientists learn about microRNAs – short strands of RNA that can interfere with normal gene activity – the more obvious it becomes how closely they are associated with cancer. In a new study, scientists at The Wistar Institute and their colleagues have identified two microRNAs (miRNAs) that promote tumors’ deadly spread, or metastasistermterm. One of the miRNAs may provide an early warning of metastaticterm breast cancer and the need for aggressive treatment.

By blocking the translation of tumor suppressor genes, miRNAs have been shown to facilitate the development of many types of cancer. In a study that will be published February 1 in Nature Cell Biology and is available online, the researchers describe how two miRNAs transformed non-invasive human breast cancer cells into cells that rapidly metastasized in cell cultures and laboratory mice.

read more | 2140 reads

Tiny radioactive spheres effectively treat cancer that has spread to the liver
By Dross at 2007-10-30 01:41

JACKSONVILLE, Fla. − Placing tiny radioactive spheres directly into the liver through its blood supply halted growth of tumors that had spread to the organ in 71 percent of patients tested in a small clinical trial, researchers from Mayo Clinic Jacksonville report.

They say that the technique appears to offer a treatment option for patients who develop multiple tumors in their liver from cancer metastasistermterm.

“Most of these patients don’t have other effective treatment options, because surgery is not possible if there are multiple tumors in their liver,” says the study’s lead investigator, Laura Vallow, M.D. “But with this radiotherapy, no new tumors developed in patients who responded and we find this to be very encouraging.”

read more | 3668 reads

EntreMed Starts Phase II Clinical Trial of Panzem with Sutent for Kidney Cancer Patients
By HCat at 2007-03-13 03:58

    EntreMed, Inc has commenced a Phase 2 trial to evaluate the safety and efficacy of Panzem (2-methoxyestradiol; 2ME2) alone or in combination with Sutenttermterm (sunitinibterm) in patients with metastaticterm renal cell carcinomaterm. The University of Wisconsin, Paul P. Carbone Comprehensive Cancer Center will be the main center conducting the trial under the guidance of Dr. Glenn Liu. The trial will investigate Panzem’s potential to treat patients who are progressing on sunitinib.

     Panzem NCD uses Elan Drug Delivery's (Elan) NanoCrystal Colloidal Dispersion (NCD) technology, a technology that is being used in marketed pharmaceuticals. The NCD technology produces nanometer-sized particles, which are up to 500 times smaller than particles manufactured by conventional milling techniques. Panzem NCD works by blocking the VEGFterm receptor and by inhibiting HIF-1alpha. The theory behind Panzem’s anti-tumor effects is that renal cell cancers are frequently associated with VEGF and PDGF overexpression involving a HIF-1alpha mechanism. It is thought that patients who progress through the tyrosine kinase inhibitor response, such as those on the tyrosine kinase inhibitor sunitinib, have an increase in HIF-1alpha expression to compensate for the kinase inhibition in order to continue tumor growth. Dr. Liu has stated that this trial will test this hypothesis. Panzem NCD is also currently in Phase 2 clinical trials for brain, ovarian, carcinoid, and prostate cancers as well as in Phase 1 study in metastatic breast cancer.

read more | 6441 reads

One Breast Cancer Therapy Could Have Counter-Productive Effects
By HCat at 2007-02-08 07:36

    A potential side effect of cancer patients treated with chemotherapyterm is a decrease of white blood cells. Cytotoxic chemotherapeutic agents work by destroying fast-proliferative cells. Unfortunately chemotherapy does not distinguish between normal and cancerous cells, thus normal fast-growing cells could also be destroyed. One group of cells that are affected by chemotherapy is white blood cells. White blood cells are needed by the immune system to fight infections, and the reduction in white blood cells may result in febrile neutropenia, a fever caused by reduced white blood cell count. Breast cancer patients treated with chemotherapy are often also treated with granulocyte-monocyte colony stimulating factor (GM-CSF).

read more | 1 comment | 4979 reads

Metastasis, the real problem
By HCat at 2007-01-03 21:42

    Although this process is inefficient, metastasistermterm is the cause of 90% of human cancer deaths. Metastasis is a complex process where cells from the primary tumor migrate to distant organs and create new tumors. It has been shown in models that when cells from metastaticterm colon cancer are injected into mice, only 0.01% survive to create new sites. This article explores some of the steps involved in metastasis with a view about the role apoptosis plays in the events. Apoptosis is the orderly program by which cells die. As opposed to necrosis which is accidental cell death from acute injury, apoptosis is signaled to cells that have received cellular damage but can still function.

read more | 3823 reads

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