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Breast
New study helps to explain why breast cancer often spreads to the lung
By Dross at 2014-04-24 23:17
 

New research led by Alison Allan, PhD, a scientist at Western University and the Lawson Health Research Institute, shows why breast cancer often spreads or metastasizes to the lung. Breast cancer is the number one diagnosed cancer and the number two cause of cancer-related deaths among women in North America. If detected early, traditional chemotherapyterm and radiation have a high success rate, but once the disease spreads beyond the breast, many conventional treatments fail.

 

read more | 17904 reads

Researchers Identify New Pathway, Enhancing Tamoxifen to Tame Aggressive Breast Cancer
By Dross at 2013-04-24 23:48
 

Tamoxifen is a time-honored breast cancer drug used to treat millions of women with early-stage and less-aggressive disease, and now a University of Rochester Medical Center team has shown how to exploit tamoxifen’s secondary activities so that it

read more | 1 comment | 4008 reads

Diagnostic accuracy may be improved via 3D scanning technique
By admin at 2012-11-21 20:08
 

According to the results of a new multi-center study published in the journal Radiology, the use of three-dimensional breast imaging, known as tomosynthesis, could improve diagnostic accuracy.

read more | 12 comments | 2717 reads

Drop in breast cancer rates directly tied to reduced hormone therapy
By Dross at 2010-11-30 22:46
 

In a new UCSF study of more than 2 million mammogram screenings performed on nearly 700,000 women in the United States, scientists for the first time show a direct link between reduced hormone therapy and declines in ductal carcinomaterm in situ (DCIS) as well as invasive breast cancer. The researchers saw such a striking decrease, they believe they also have uncovered indirect evidence that hormones promote breast tumor growth.

read more | 2221 reads

Sporadic breast cancers start with ineffective DNA repair systems, Pitt researchers find
By Dross at 2010-11-30 05:13
 

 PITTSBURGH, Nov. 29 – Breast cancers that arise sporadically, rather than through inheritance of certain genes, likely start with defects of DNA repair mechanisms that allow environmentally triggered mutations to accumulate, according to researchers at the University of Pittsburgh School of Medicine, Magee-Womens Hospital of UPMC and the University of Pittsburgh Cancer Institute.

read more | 2020 reads

Women with personal history of breast cancer should be screened with MRI
By Dross at 2010-11-29 21:29
 


CHICAGO – Women with a personal history of breast cancer should consider annual screening with MRI in addition to mammography, according to a study presented today at the annual meeting of the Radiological Society of North America (RSNA).

read more | 1769 reads

Too much of a good thing: Important mechanism in hormone-sensitive breast cancer uncovered
By Dross at 2010-11-24 21:44
 

Two thirds of breast cancers are ERalpha-positive, i.e., many estrogen receptors of the ERalpha- type are found in their cells. "These molecules can interact with the estrogen hormone and, thus, even lead to cancer," explains Dr. Joerg Hoheisel; molecular biologist at DKFZ. "The connection between the levels of the estrogen receptor alpha and the occurrence of breast cancer has been known for some time now. Early-stage breast cancer cells already produce too many of these receptors.

read more | 1836 reads

Discovery halts breast cancer stem cells
By Dross at 2010-11-24 21:41
 

BOSTON (Nov. 23, 2010) —Breast cancer stem cells (CSCs), the aggressive cells thought to be resistant to current anti-cancer therapies and which promote metastasistermterm, are stimulated by estrogen via a pathway that mirrors normal stem cell development. Disrupting the pathway, researchers were able to halt the expansion of breast CSCs, a finding that suggests a new drug therapy target.

read more | 12 comments | 2001 reads

Age 50 as mammography screening threshold proven unfounded
By Dross at 2010-09-30 21:19
 

The landmark breast cancer screening study of women 40-49, published online in Cancer, has proven that annual mammography screening of women in their 40s reduces the breast cancer death rate in these women by nearly 30 percent. The results of this largest study ever conducted on women in this age group confirm that the use of the age of 50 as a threshold for breast cancer screening is scientifically unfounded. Women should begin getting annual mammograms at age 40.

read more | 12 comments | 2697 reads

Watercress may turn off breast cancer signal
By Dross at 2010-09-15 05:32
 

New scientific research from the University of Southampton has revealed that a plant compound in watercress may have the ability to suppress breast cancer cell development by 'turning off' a signal in the body and thereby starving the growing tumour of essential blood and oxygen. The research, unveiled at a press conference today (14 September 2010), shows that the watercress compound is able to interfere with the function of a protein which plays a critical role in cancer development.

read more | 2065 reads

Experts issue call to reconsider screening for breast cancer and prostate cancer
By Dross at 2009-10-21 18:13
 

Twenty years of screening for breast and prostate cancer – the most diagnosed cancer for women and men – have not brought the anticipated decline in deaths from these diseases, argue experts from the University of California, San Francisco and the University of Texas Health Science Center at San Antonio in an opinion piece published in the "Journal of the American Medical Association."

read more | 1 comment | 2357 reads

Study examines mastectomy and breast-conserving surgery rates
By Dross at 2009-10-15 10:43
 

There is concern that mastectomy is over-utilized in the United States, which raises questions about the role of surgeons and patient preference in treatment selection for breast cancer. New data from an observational study found that breast-conserving surgery was presented and provided in the majority of patients evaluated. Surgeon recommendations, patient decisions, and failure of breast-conserving surgery were all found to be contributing factors to the mastectomy rate.

read more | 3 comments | 2064 reads

Discovery leads to rapid mouse 'personalized trials' in breast cancer
By Dross at 2009-09-09 03:25
 

DURHAM, N.C. -- One person's breast cancer is not the same as another person's, because the gene mutations differ in each tumor. That makes it difficult to match the best therapy with the individual patient.

Using a finding that the genetic complexity of tumors in mice parallels that in humans, researchers at the Duke University Institute for Genome Sciences and Policy and Duke University Medical Center are starting trial studies in mice, just like human clinical trials, to evaluate whether understanding tumor diversity can improve cancer treatment.

read more | 1 comment | 1893 reads

Researchers pinpoint a new enemy for tumor-suppressor p53
By Dross at 2009-06-28 07:19
 

HOUSTON - Researchers at The University of Texas M. D. Anderson Cancer Center have identified a protein that marks the tumor suppressor p53 for destruction, providing a potential new avenue for restoring p53 in cancer cells.

The new protein, called Trim24, feeds p53 to a protein-shredding complex known as the proteasome by attaching targeting molecules called ubiquitins to the tumor suppressor, the team reported this week in the Proceedings of the National Academy of Sciences Online Early Edition.

read more | 2407 reads

CSHL scientists identify new drug target against virulent type of breast cancer
By Dross at 2008-08-25 21:12
 
The enzyme target, Brk, is shown to be an accelerator of HER2-positive tumors

Tumor cells in a particular subset of breast cancer patients churn out too much of a protein called ErbB2 -- also often called HER2 -- which drives the cells to proliferate unchecked. Patients unlucky enough to be in this group -- about one in four -- have poorer prognoses and clinical outcomes than those who don't.

The drugs Herceptin and Lapatinib, prescribed in combination with other chemotherapeutic agents, have improved this picture significantly, but leave plenty of room for improvement: they suppress ErbB2 but are effective against less than half of ErbB2-producing tumors. Moreover, patients with tumors that do respond usually develop resistance to these drugs.

read more | 1 comment | 2711 reads

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